izindaba

Ukubuyekezwa kwakamuva okushicilelwe ithimba labacwaningi besayensi baseCanada kuphakamisa ukuthi ama-cannabinoids angase abambe iqhaza ekuvimbeleni nasekwelapheni i-COVID-19 kanye ne-COVID yesikhathi eside.

Ekubuyekezeni okupheleleyo, iqembu lososayensi baseCanada linikeza ukuqonda okuthakazelisayo ngendima engaba khona yama-cannabinoids ekulweni negciwane le-COVID-19.Lolu cwaningo, olunesihloko esithi "Cannabinoids kanye ne-Endocannabinoid System in Early SARS-CoV-2 kanye ne-Chronic COVID-19 Patients," lubhalwe nguCassidy Scott, uStefan Hall, Juan Zhou, Christian Lehmann nabanye futhi lwanyatheliswa ku-Journal of SARS-CoV. -2″ umagazini.

Imithi Yokwelapha.Ngokuhlaziya idatha eningi evela ezifundweni ezedlule, umbiko uxoxa ngokuthi izingxenye zesitshalo sensangu zingadlala kanjani indima ebalulekile ekuvimbeleni ukuqala kwe-COVID-19 kanye nokunciphisa imiphumela yayo yesikhathi eside.Okutholakele kusikisela ukuthi ama-cannabinoids, ikakhulukazi lawo akhishwe esitshalweni se-cannabis, angavimbela ukungena kwegciwane kumaseli, anciphise ingcindezi ye-oxidative eyingozi, futhi acindezele ukuphendula okuvame ukubulawa kwamasosha omzimba abonakala ezimeni ezinzima.Ucwaningo luphinde lugqamise indima engaba khona yama-cannabinoids ekubhekaneni nezimpawu ezahlukahlukene eziqhubekayo ze-COVID-19 yesikhathi eside.

Ngokusho kocwaningo, ama-cannabinoids anamandla okuvimbela ukungena kwegciwane, ehlise ingcindezi ye-oxidative futhi ehlise isiphepho se-cytokine esihlobene negciwane le-COVID-19.Ucwaningo lubonisa lokho okuqondileama-cannabinoid extractsingakwazi ukulawula amazinga e-angiotensin-converting enzyme 2 (ACE2) ezicutshini ezibalulekile, ngaleyo ndlela ivimbele amagciwane ukuthi angene kumaseli omuntu.Abacwaningi bayaqaphela ukuthi lokhu kubalulekile uma kubhekwa indima ye-ACE2 njengesango eliyinhloko lokungena ngegciwane.Lo mbiko ubuye uxoxe ngeqhaza lama-cannabinoids ekubhekaneni nengcindezi ye-oxidative, into ebalulekile ku-pathogenesis ye-COVID-19.

Ngokuguqula ama-radicals wamahhala abe amafomu angasebenzi kancane, ama-cannabinoids afanaI-CBDkungasiza ekwehliseni imiphumela eyingozi yengcindezi ye-oxidative ezimeni ezinzima ze-COVID-19.Ngokusho kocwaningo, ama-cannabinoids angase abe nemiphumela enenzuzo ezivunguvungwini ze-cytokine, impendulo eqinile yokuzivikela komzimba ebangelwa i-COVID-19.Ama-cannabinoids akhonjiswe ukuthi ayasebenza ekwehliseni ama-cytokines avuvukalayo, ephakamisa amandla awo ekulawuleni izimpendulo ezinjalo zokuzivikela komzimba.

I-COVID ende isho isimo esivame ukwenzeka njengokudlulela kwe-COVID-19 kuya esigabeni esingamahlalakhona.Ucwaningo luveza amandla e-cannabinoids ekwelapheni izimpawu eziqhubekayo zokucindezeleka, ukukhathazeka, ukuphazamiseka kwengcindezi yangemva kwesigameko, ukuqwasha, ubuhlungu kanye nokulahlekelwa ukudla.Uhlelo lwe-endocannabinoid ludlala indima ekusebenzisaneni kwezinhlelo ezihlukahlukene zezinzwa, okwenza kube okuqondiwe ekwelapheni lezi zimpawu ze-neuropsychiatric.

Ucwaningo luphinde lwahlola izindlela ezahlukahlukene zokusebenzisa kanye nezinhlobo ezahlukahlukene zemikhiqizo yensangu esetshenziswa abathengi.Ucwaningo lubonisa ukuthi ukumunca ngokuhogela kungase kube nemiphumela engemihle kubantu abanezimo zokuphefumula, okuphikisa imiphumela yako yokwelapha."Yize ukubhema kanye ne-vaping ngokuvamile kuyizindlela ezithandwayo ezigulini ze-cannabis ngoba ziqala ngokushesha, izinzuzo ezingaba khona zokwelashwa kwe-cannabinoid zingase zisuswe yimiphumela emibi yokuhogela empilweni yokuphefumula," kusho abacwaningi.Ucwaningo lubonisa "Iziguli ezisebenzisa i-cannabis vaporization ziba nezimpawu ezimbalwa zokuphefumula kunokubhema ngoba isisetshenziswa esikhipha umhwamuko asishisi insangu ize ifike lapho isha khona."Ababhali balo mbiko bagcizelela isidingo sokuthi kwenziwe olunye ucwaningo kule ndawo.Yize okutholwe okokuqala kukhuthaza, bayaxwayisa ngokuthi kungokokuqala futhi kuvela ezifundweni ezingaqondile ku-COVID-19.Ngakho-ke, izifundo eziqondiswe kakhulu neziphelele, okuhlanganisa nezilingo zomtholampilo, zibalulekile ukuze uqonde ngokugcwele indima nokusebenza ngempumelelo kwama-cannabinoids ekwelapheni ukutheleleka kwe-SARS-CoV-2 esigabeni sokuqala nesibi.Ngaphezu kwalokho, ababhali bakhuthaza ukuthi kwenziwe ucwaningo olunzulu nge-pharmacology kanye nezinhlelo zokwelapha ezingase zibe khona zohlelo lwe-endocannabinoid futhi banxuse umphakathi wesayensi ukuthi uhlole le ndlela ngokucophelela.